Immune Responses to Irradiated Pneumococcal Whole Cell Vaccine
نویسندگان
چکیده
منابع مشابه
Immune responses to recombinant pneumococcal PsaA antigen delivered by a live attenuated Salmonella vaccine.
Streptococcus pneumoniae is a leading cause of morbidity and mortality among children worldwide and particularly in developing countries. In this study, we evaluated PsaA, a conserved antigen important for S. pneumoniae adhesion to and invasion into nasopharynx epithelia, for its ability to induce protective immunity against S. pneumoniae challenge when delivered by recombinant attenuated Salmo...
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Attenuated Salmonella enterica serovar Typhimurium expressing recombinant antigens from other pathogens elicits primarily a Th1-type dominant immune response to both recombinant and Salmonella antigens. The immunogenicity and appropriate subcellular location of the recombinant antigen in the Salmonella vaccine strain may contribute to augmenting immune responses by facilitating adequate exposur...
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Macrolide antibiotics, including azithromycin, have been implicated in the modulation of host immune responses, independently of their antimicrobial properties. The present work was designed to study the effect that azithromycin has on protective humoral immune responses induced by a 7-valent, polysaccharide, pneumococcal conjugate vaccine (PCV7). By use of a murine vaccination/challenge model,...
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The immune response of lymphocytes to subcutaneously administered pneumococcal vaccine was studied in five patients without spleens and in five healthy subjects. Seven days after immunisation circulating B cells synthesising IgG antipneumococcal capsular polysaccharides (anti-PCP) appeared in both groups. Twenty one days after vaccination this B cell population had disappeared and a B cell subs...
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chronic carriers worldwide.1 The highest carrier rate is in Asia and Africa. 2 Chronic infection develops among 90% of newborns, 29-40% of children and 5-10% of adults.3 Patients with long-standing active liver disease are at high risk of developing liver cirrhosis and hepatocellular carcinoma.4 Hepatitis B virus is responsible for 80% of liver cancer cases in the world.5 Therefore, prevention ...
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ژورنال
عنوان ژورنال: Vaccines
سال: 2021
ISSN: 2076-393X
DOI: 10.3390/vaccines9040405